Dimetindene

Dimetindene, also sold under the brand name Fenistil, is an antihistamine/anticholinergic. It is a first generation^[1] selective H1 antagonist.^[2] Dimetindene is an atypical first generation H1 antagonist as it only minimally^[3] passes across the blood–brain barrier.

Dimetindene

Clinical data
Trade names	Fenistil
AHFS/Drugs.com	International Drug Names
Routes of administration	Oral, topical
ATC code	D04AA13 (WHO) R06AB03 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) UK: General sales list (GSL, OTC)
Identifiers
IUPAC name N,N-Dimethyl-2-[3-(1-pyridin-2-ylethyl)-1H-inden-2-yl]ethan-1-amine
CAS Number	5636-83-9 Y 3614-69-5
PubChem CID	21855
DrugBank	DB08801 Y
ChemSpider	20541 Y
UNII	661FH77Z3P
KEGG	D07853 Y
ChEMBL	ChEMBL22108 Y
CompTox Dashboard (EPA)	DTXSID9022942
ECHA InfoCard	100.024.622
Chemical and physical data
Formula	C20H24N2
Molar mass	292.426 g·mol−1
3D model (JSmol)	Interactive image
Chirality	Racemic mixture
SMILES n1ccccc1C(C=3c2ccccc2CC=3CCN(C)C)C
InChI InChI=1S/C20H24N2/c1-15(19-10-6-7-12-21-19)20-17(11-13-22(2)3)14-16-8-4-5-9-18(16)20/h4-10,12,15H,11,13-14H2,1-3H3 Y Key:MVMQESMQSYOVGV-UHFFFAOYSA-N Y
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Dimetindene is also an M2 receptor antagonist.^[4]

It was patented in 1958 and came into medical use in 1960.^[5]

Medical use

Dimetindene is used orally and topically as an antipruritic.^[6] It is used topically to treat skin irritations, such as insect bites. Dimetindene is also administered orally to treat allergies, such as hay fever.

It is commonly formulated as its maleic acid salt, dimethindene maleate.

Names

It is sold under the brand name Fenistil among others.