1-(2-Diphenyl)piperazine

1-(2-Diphenyl)piperazine, also known as RA-7, is a drug that acts as a potent and selective antagonist at the 5HT₇ serotonin receptor. It was discovered as an active metabolite of the synthetic 5-HT₇ agonists LP-12 and LP-211 and unexpectedly turned out to be a potent antagonist with selectivity approaching that of the parent molecules, despite its much simpler structure.^[1]

1-(2-Diphenyl)piperazine

Identifiers
IUPAC name 1-(2-diphenyl)piperazine
CAS Number	180698-18-4 Y
PubChem CID	2737389
ChemSpider	2019031 Y
UNII	T5S5265H6V
ChEMBL	ChEMBL494675 Y
CompTox Dashboard (EPA)	DTXSID901029791
Chemical and physical data
Formula	C16H18N2
Molar mass	238.334 g·mol−1
3D model (JSmol)	Interactive image
SMILES C3CNCCN3c1ccccc1-c2ccccc2
InChI InChI=1S/C16H18N2/c1-2-6-14(7-3-1)15-8-4-5-9-16(15)18-12-10-17-11-13-18/h1-9,17H,10-13H2 Y Key:RKRVRTJVCWZOQS-UHFFFAOYSA-N Y
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See also

• Benzylpiperazine
• Naphthylpiperazine
• Phenylpiperazine