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Drospirenone/estetrol
Pharmaceutical combination From Wikipedia, the free encyclopedia
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Drospirenone/estetrol, sold under the brand name Nextstellis, among others, is a fixed-dose combination medication containing drospirenone, a progestin, and estetrol, an estrogen, which is used as a combined birth control pill for the prevention of pregnancy in women.[2][6] It is taken by mouth.[2][6]
It was approved for medical use in Canada in March 2021,[3] and in the United States in April 2021.[6]
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Medical uses
Drospirenone/estetrol is used as a combined birth control pill to prevent pregnancy in women.[2][6]
Side effects
Estetrol-containing birth control pills, similarly to estradiol-containing birth control pills, may have a lower risk of venous thromboembolism (VTE) than ethinylestradiol-containing birth control pills based on studies of coagulation.[11][12] However, it is likely that another decade will be required before post-marketing epidemiological studies of VTE incidence with these birth control pills are completed and able to confirm this.[13]
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Pharmacology
Pharmacodynamics
Drospirenone/estetrol has a much lower impact on liver protein synthesis, including of sex hormone-binding globulin, angiotensinogen, and coagulation factors, than does ethinylestradiol/drospirenone.[14]
Society and culture
Legal status
Drospirenone/estetrol is approved for the use of hormonal contraception in the European Union,[7][8] the United States,[15] and Canada.[3]
Brand names
Drospirenone/estetrol in sold under the brand names Nexstellis,[3] Drovelis,[7] and Lydisilka.[8]
See also
References
External links
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