Evolutionary Classification of Protein Domains

The Evolutionary Classification of Protein Domains (ECOD) is a biological database that classifies protein domains available from the Protein Data Bank. The ECOD tries to determine the evolutionary relationships between proteins.

ECOD

Content
Data types captured	Protein domains
Contact
Research center	Grishin Lab, University of Texas Southwestern Medical Center
Authors	H. Cheng, R. D. Schaeffer, Y. Liao, L. N. Kinch, J. Pei, S. Shi, B. H. Kim, N. V. Grishin.
Primary citation	PMID 25474468
Release date	2014
Access
Website	http://prodata.swmed.edu/ecod/
Miscellaneous
Version	continuously updated
Curation policy	manual for new proteins; automated for ones with close matches

Similar to Pfam, CATH, and SCOP, ECOD compiles domains instead of whole proteins. However, ECOD focuses on evolutionary relationships more heavily: instead of grouping proteins by folds, which may simply represent convergent evolution, ECOD groups proteins by demonstratable homology only.^[1]