Malonyl CoA reductase (malonate semialdehyde-forming)

Malonyl CoA reductase (malonate semialdehyde-forming) (EC 1.2.1.75, NADP-dependent malonyl CoA reductase, malonyl CoA reductase (NADP)) is an enzyme with systematic name malonate semialdehyde:NADP⁺ oxidoreductase (malonate semialdehyde-forming).^[1][2][3][4] This enzyme catalyse the following chemical reaction

malonate semialdehyde + CoA + NADP⁺ ${\displaystyle \rightleftharpoons }$ malonyl-CoA + NADPH + H⁺

Malonyl CoA reductase (malonate semialdehyde-forming)
Identifiers
EC no.	1.2.1.75
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
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Requires Mg²⁺. Catalyses the reduction of malonyl-CoA to malonate semialdehyde.