ETV4

ETS translocation variant 4 (ETV4), also known as polyoma enhancer activator 3 (PEA3), is a member of the PEA3 subfamily of Ets transcription factors.^[5][6][7]

ETV4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4CO8, 4UUV
Identifiers
Aliases	ETV4, E1A-F, E1AF, PEA3, PEAS3, ETS variant 4, ETS variant transcription factor 4
External IDs	OMIM: 600711; MGI: 99423; HomoloGene: 1504; GeneCards: ETV4; OMA:ETV4 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.31 Start 43,527,844 bp[1] End 43,579,620 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 65.48 cM Start 101,660,568 bp[2] End 101,676,197 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad pituitary gland testicle anterior pituitary mucosa of pharynx pericardium nipple sural nerve gallbladder skin of limb Top expressed in palate soft palate tail of embryo cardiac muscle tissue of left ventricle lip palatoglossus muscle epiblast extensor digitorum longus muscle urethra tongue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding sequence-specific DNA binding DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleoplasm nucleolus nucleus Biological process cell differentiation regulation of transcription, DNA-templated transcription, DNA-templated transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2118 18612 Ensembl ENSG00000175832 ENSMUSG00000017724 UniProt P43268 P28322 RefSeq (mRNA) NM_001079675 NM_001261437 NM_001261438 NM_001261439 NM_001986 NM_001369366 NM_001369367 NM_001369368 NM_008815 NM_001316365 NM_001316366 RefSeq (protein) NP_001073143 NP_001248366 NP_001248367 NP_001248368 NP_001977 NP_001356295 NP_001356296 NP_001356297 NP_001303294 NP_001303295 NP_032841 Location (UCSC) Chr 17: 43.53 – 43.58 Mb Chr 11: 101.66 – 101.68 Mb PubMed search [3] [4]
Wikidata
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Disease marker

Two variants of a disease associated with ETV4 is Ewing Sarcoma and Extraosseous Ewing's Sarcoma. While both are cancerous tumors, the former grows in the bones most commonly affecting the arms, legs, hips, and spine, while the later affects the soft tissue in the chest, foot, pelvis and spine.