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Enamel-renal syndrome
Medical condition From Wikipedia, the free encyclopedia
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Enamel-renal syndrome is a rare autosomal recessive condition.[1] This condition is also known as idiopathic multicentric osteolysis with nephropathy. It is characterised by dental abnormalities and nephrocalcinosis.
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Presentation
The dental abnormalities include
- hypoplastic amelogenesis imperfecta
- microdontia
- intra-pulpal calcification
- impacted posterior teeth with hyperplastic pericoronal follicles
- gingival fibromatosis
- ectopic calcifications on gingival and pericoronal tissues
Genetics
This condition is caused by mutations in the FAM20A gene. This gene encodes a protein – the Golgi apparatus associated secretory pathway pseudokinase. The gene is located on the long arm of chromosome 17 (17q24.2).[citation needed]
Pathogensis
The protein is an allosteric activator of the Golgi serine/threonine protein kinase and is involved in biomineralization of teeth.
Diagnosis
The diagnosis may be suspected on the basis of the constellation of clinical features. It is made by sequencing the FAM20A gene.
This condition is usually diagnosed in childhood but may not be recognised until early adulthood. The diagnosis is suspected on the combination of nephrocalcinosis and dental abnormalities.[citation needed]
Differential diagnosis
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Treatment
There is no specific treatment for this condition currently known and management of its various features is the norm.[citation needed]
History
This condition was first described in 1972.[2]
References
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