Endoglycosylceramidase

The enzyme endoglycosylceramidase (EC 3.2.1.123) catalyzes the following chemical reaction:

oligoglycosylglucosylceramide + H₂O ${\displaystyle \rightleftharpoons }$ ceramide + oligoglycosylglucose

endoglycosylceramidase
Identifiers
EC no.	3.2.1.123
CAS no.	105503-61-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name is oligoglycosylglucosylceramide glycohydrolase. Other names in common use include endoglycoceramidase, EGCase, and glycosyl-N-acetyl-sphingosine 1,1-β-D-glucanohydrolase.

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 2OSW, 2OSX, 2OSY, 2OYK, 2OYL, and 2OYM.