Ent-kaurene synthase

The enzyme ent-kaurene synthase (EC 4.2.3.19) catalyzes the chemical reaction

ent-copalyl diphosphate ${\displaystyle \rightleftharpoons }$ ent-kaurene + diphosphate

ent-kaurene synthase
Identifiers
EC no.	4.2.3.19
CAS no.	9055-64-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is ent-copalyl-diphosphate diphosphate-lyase (cyclizing, ent-kaurene-forming). Other names in common use include ent-kaurene synthase B, ent-kaurene synthetase B, ent-copalyl-diphosphate diphosphate-lyase, and (cyclizing). This enzyme participates in diterpenoid biosynthesis.

In Stevia

In Stevia spp., ent-kaurene synthase is a required part of the biosynthesis of steviol.^[1][2] Hajihashemi et al., 2013 find that it is involved in the drought stress response and – because it mimics drought stress – paclobutrazol toxicity.^[1][2] Both inhbit transcription of steviol glycoside synthesis genes including ent-kaurene synthase.^[1][2] This is believed to reduce steviol content in the final plant product.^[1][2]