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Heck's disease
Medical condition From Wikipedia, the free encyclopedia
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Heck's disease, also known as focal (or multifocal) epithelial hyperplasia, is an asymptomatic, benign neoplastic condition characterized by multiple white to pinkish papules that occur diffusely in the mouth.[1][2]: 411 It can present with slightly pale, smooth or roughened surface morphology. It is caused by the human papilloma virus types 13 and 32.[3] It exhibits surface cells with vacuolated cytoplasm around irregular, pyknotic nuclei and occasional cells with mitosis-like changes within otherwise mature and well-differentiated epithelium. A distinguishing histologic feature is elongated rete ridges with mitosoid bodies. It shows "cobblestone" appearance clinically. It was first identified among young Native American patients in the 1960s.[4]
Over time, the papules will spontaneously regress without treatment.[5] Possible treatment may be excisional biopsy for lesions of functional or aesthetic concern.[citation needed]
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