Epstein–Barr virus small nucleolar RNA 1

V-snoRNA1 is a box CD-snoRNA^{[clarification needed]} identified in B lymphocytes infected with the Epstein–Barr virus (human herpesvirus 4 (HHV-4)).^[1] This snoRNA is the first known example of a snoRNA expressed from a viral genome.^[2] It is homologous to eukaryotic snoRNAs because it contains the C and D boxes sequence motifs^{[clarification needed]} but lacks a terminal stem-loop structure. The nucleolar localization of v-snoRNA1 was determined by in situ hybridization. V-snoRNA1 can form into a ribonucleoprotein complex (snoRNP) as co-immunoprecipitation (CoIP) assays showed that this snoRNA interacts with the snoRNA core proteins, fibrillarin, Nop56, Nop58.^{[clarification needed]} It has also been proposed that this snoRNA may act as a miRNA-like precursor that is processed into 24-nucleotide-sized RNA fragments that target the 3'UTR^{[clarification needed]} of viral DNA polymerase mRNA.^[1]

Human herpesvirus 1 small nucleolar RNA
Sequence concservation of v-snoRNA1
Identifiers
Symbol	v-snoRNA1
Rfam	RF01516
Other data
RNA type	snoRNA
PDB structures	PDBe

See also

• Epstein–Barr virus stable intronic sequence RNAs