Nomegestrol acetate/estradiol

Nomegestrol acetate/estradiol (NOMAC-E2), sold under the brand names Naemis and Zoely among others, is a fixed-dose combination medication of nomegestrol acetate, a progestogen, and estradiol, an estrogen, which is used in menopausal hormone therapy and as a birth control pill to prevent pregnancy in women.^[3] It is taken by mouth.

Nomegestrol acetate/estradiol

Estradiol (top) and nomegestrol acetate (bottom)
Combination of
Nomegestrol acetate	Progestogen
Estradiol	Estrogen
Clinical data
Trade names	Zoely
Other names	NOMAC-E2, NOMAC/E2, MK-8175A
AHFS/Drugs.com	UK Drug Information
Routes of administration	By mouth
Drug class	Estrogen; Progestogen
ATC code	G03AA14 (WHO)
Legal status
Legal status	UK: POM (Prescription only)[1] EU: Rx-only[2]
Identifiers
CAS Number	853244-42-5
PubChem CID	9895694
KEGG	D10856

Research

Estradiol-containing birth control pills like NOMAC-E2 may have a lower risk of venous thromboembolism than birth control pills containing ethinylestradiol.^[4] This is being studied in the case of NOMAC-E2.^[4][5]

See also

• List of combined sex-hormonal preparations