HDEP-28

HDEP-28 or ethylnaphthidate is a stimulant drug of the piperidine and naphthylaminopropane groups, closely related to ethylphenidate, but with the benzene ring replaced by naphthalene. It is even more closely related to HDMP-28, which acts as a potent serotonin–norepinephrine–dopamine reuptake inhibitor with several times the potency of methylphenidate and a short duration of action.^[1] It has been sold as a designer drug since around 2015.^[2]

HDEP-28

Legal status
Legal status	CA: Schedule III DE: NpSG (Industrial and scientific use only) UK: Class B
Identifiers
IUPAC name Ethyl (naphthalen-2-yl)(piperidin-2-yl)acetate
CAS Number	2170529-69-6
PubChem CID	91844468
ChemSpider	52085106
UNII	A8326SH248
CompTox Dashboard (EPA)	DTXSID601336139
Chemical and physical data
Formula	C19H23NO2
Molar mass	297.398 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCOC(=O)C(C1CCCCN1)c2ccc3ccccc3c2
InChI InChI=1S/C19H23NO2/c1-2-22-19(21)18(17-9-5-6-12-20-17)16-11-10-14-7-3-4-8-15(14)13-16/h3-4,7-8,10-11,13,17-18,20H,2,5-6,9,12H2,1H3 Key:OTQVTBPHZRARTL-UHFFFAOYSA-N

Legality

HDEP-28 was banned in the UK as a Temporary Class Drug from June 2015 following its unapproved sale as a designer drug, alongside 4-Methylmethylphenidate.^[3][4][5]

See also

• 2β-Propanoyl-3β-(2-naphthyl)-tropane (WF-23)
• 3,4-Dichloromethylphenidate
• 4-Methylmethylphenidate
• 4-Fluoromethylphenidate
• Isopropylphenidate
• Naphthylisopropylamine
• Naphyrone
• Propylphenidate