Pseudomonas exotoxin

The Pseudomonas exotoxin (or exotoxin A) is an exotoxin produced by Pseudomonas aeruginosa.^[1] Vibrio cholerae produces a similar protein called the Cholix toxin (Q5EK40).^[2]

Exotoxin A
Exotoxin A dimer, Pseudomonas aeruginosa
Identifiers
Organism	Pseudomonas aeruginosa
Symbol	eta
UniProt	P11439
Other data
EC number	2.4.2.36
Search for Structures Swiss-model Domains InterPro

For the Streptococcal superantigen SpeA, also referred to as exotoxin A, see Erythrogenic toxin.

It inhibits elongation factor-2. It does so by ADP-ribosylation of EF2 using NAD+. This then causes the elongation of polypeptides to cease. This mechanism is similar to that of diphtheria toxin.^[3]

It has been investigated as a treatment for hepatitis B^[4] and cancer.^[5]