FGF-2 internal ribosome entry site (IRES)

The FGF-2 internal ribosome entry site is an RNA element present in the 5' UTR of the mRNA of fibroblast growth factor-2. It has been found that the FGF-2 internal ribosome entry site (IRES) activity is strictly controlled and highly tissue specific. It is thought that translational IRES dependent activation of FGF-2 plays a vital role in embryogenesis and in the adult brain [1]. When expressed the fibroblast growth factor 2 FGF-2 protein plays a pivotal role in cell proliferation, differentiation and survival as well as being involved in wound-healing [1,2].

FGF-2 internal ribosome entry site (IRES)
Predicted secondary structure and sequence conservation of IRES_FGF2
Identifiers
Symbol	IRES_FGF2
Alt. Symbols	IRES_FGF; FGF_IRES
Rfam	RF00224
Other data
RNA type	Cis-reg; IRES
Domain	Eukaryota
GO	GO:0043022
SO	SO:0000243
PDB structures	PDBe