Dimethylallyltranstransferase

Dimethylallyltranstransferase (DMATT), also known as farnesylpyrophosphate synthase (FPPS) or as farnesyldiphosphate synthase (FDPS), is an enzyme that in humans is encoded by the FDPS gene and catalyzes the transformation of dimethylallylpyrophosphate (DMAPP) and isopentenyl pyrophosphate (IPP) into farnesylpyrophosphate (FPP).^[5][6]

FDPS
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1YQ7, 1YV5, 1ZW5, 2F7M, 2F89, 2F8C, 2F8Z, 2F92, 2F94, 2F9K, 2OPM, 2OPN, 2QIS, 2RAH, 2VF6, 3B7L, 3CP6, 3N1V, 3N1W, 3N3L, 3N45, 3N46, 3N49, 3N5H, 3N5J, 3N6K, 3RYE, 3S4J, 4DEM, 4GA3, 4H5C, 4H5D, 4H5E, 4JVJ, 4KFA, 4KPD, 4KPJ, 4KQ5, 4KQS, 4KQU, 4L2X, 4LFV, 4LPG, 4LPH, 4N1Z, 4N9U, 4NFI, 4NFJ, 4NFK, 4NG6, 4NKE, 4NKF, 4NUA, 4OGU, 4P0V, 4P0W, 4P0X, 4PVX, 4PVY, 4Q23, 4QPF, 4QXS, 4RXA, 4XQR, 5CG5, 5DIQ, 5CG6, 5DJR, 5DJP, 4XQS, 5DJV, 5DGN, 4XQT, 5DGM, 5DGS
Identifiers
Aliases	FDPS, FPPS, FPS, POROK9, farnesyl diphosphate synthase
External IDs	OMIM: 134629; MGI: 104888; HomoloGene: 1519; GeneCards: FDPS; OMA:FDPS - orthologs
EC number	2.5.1.1
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q22 Start 155,308,748 bp[1] End 155,320,666 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F1|3 39.01 cM Start 89,000,895 bp[2] End 89,009,266 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone mucosa of transverse colon ganglionic eminence right adrenal gland skin of thigh tendon of biceps brachii right adrenal cortex right lobe of liver upper lobe of left lung mucosa of esophagus Top expressed in Mesencephalon neural tube morula lip esophagus hepatobiliary system exocrine gland liver ovary adrenal gland More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity metal ion binding geranyltranstransferase activity dimethylallyltranstransferase activity RNA binding Cellular component nucleoplasm cytoplasm cytosol mitochondrion Biological process cholesterol biosynthetic process steroid metabolic process viral process cholesterol metabolic process geranyl diphosphate biosynthetic process sterol biosynthetic process isoprenoid biosynthetic process lipid metabolism steroid biosynthetic process farnesyl diphosphate biosynthetic process regulation of cholesterol biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2224 110196 Ensembl ENSG00000160752 ENSMUSG00000059743 UniProt P14324 Q920E5 RefSeq (mRNA) NM_001135821 NM_001135822 NM_001242824 NM_001242825 NM_002004 NM_001378424 NM_001378425 NM_001253751 NM_134469 NM_180985 RefSeq (protein) NP_001129293 NP_001129294 NP_001229753 NP_001229754 NP_001995 NP_001365353 NP_001365354 NP_001240680 NP_608219 Location (UCSC) Chr 1: 155.31 – 155.32 Mb Chr 3: 89 – 89.01 Mb PubMed search [3] [4]
Wikidata
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Dimethylallyltranstransferase
Identifiers
EC no.	2.5.1.1
CAS no.	9032-79-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Farnesyldiphosphate synthase (farnesylpyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)
Identifiers
Symbol	FDPS
NCBI gene	2224
HGNC	3631
OMIM	134629
RefSeq	NM_002004
UniProt	P14324
Other data
EC number	2.5.1.1
Locus	Chr. 1 q22
Search for Structures Swiss-model Domains InterPro

Pyrophosphate is also involved, as both a reactant and a product. Geranylpyrophosphate is created in an intermediate step.

See also

• Geranyltranstransferase