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Ferroxidase

Iron oxidizing enzyme, Fe(II) to Fe(III) conversion From Wikipedia, the free encyclopedia

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Ferroxidase also known as Fe(II):oxygen oxidoreductase is an enzyme that catalyzes the oxidization of iron II to iron III:

4 Fe2+ + 4 H+ + O2 ⇔ 4 Fe3+ + 2H2O
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Examples

Human genes encoding proteins with ferroxidase activity include:

  • CP – Ceruloplasmin
  • FTH1 – Ferritin heavy chain
  • FTMT – Ferritin, mitochondrial
  • HEPH - Hephaestin

References

  • Cox JC, Boxer DH (1986). "The role of rusticyanin, a blue copper protein, in the electron transport chain of Thiobacillus ferrooxidans grown on iron or thiosulfate". Biotechnol. Appl. Biochem. 8: 269–275.
  • Osaki S (November 1966). "Kinetic studies of ferrous ion oxidation with crystalline human ferroxidase (ceruloplasmin)". J. Biol. Chem. 241 (21): 5053–9. doi:10.1016/S0021-9258(18)99669-9. PMID 5925868.
  • Osaki S, Walaas O (June 1967). "Kinetic studies of ferrous ion oxidation with crystalline human ferroxidase. II. Rate constants at various steps and formation of a possible enzyme-substrate complex". J. Biol. Chem. 242 (11): 2653–7. doi:10.1016/S0021-9258(18)99620-1. PMID 6027241.


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