Flavanone 4-reductase

In enzymology, a flavanone 4-reductase (EC 1.1.1.234) is an enzyme that catalyzes the chemical reaction

(2S)-flavan-4-ol + NADP⁺ ${\displaystyle \rightleftharpoons }$ (2S)-flavanone + NADPH + H⁺

flavanone 4-reductase
Identifiers
EC no.	1.1.1.234
CAS no.	115232-53-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are (2S)-flavan-4-ol and NADP⁺, whereas its 3 products are (2S)-flavanone, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (2S)-flavan-4-ol:NADP⁺ 4-oxidoreductase. This enzyme participates in flavonoid biosynthesis.