Flp/Fap Pilin putative holin family

The Flp/Fap Pilin Putative Holin (FFPP-Hol) Family (TC# 1.E.52) is a large diverse family with members from many bacterial phyla. Some members are annotated as Flp or Fap pilin subunits; others are identified as Holin BlyA family members. They range in size of 50 to 80 amino acyl residues (aas) with a single N-terminal transmembrane segment (TMS) although one member has 99 aas and 2 TMSs (TC# 1.E.52.2.1). Flp homologues are included in TCDB under TC# 3.A.7.13.1 (pXO1-63) and TC# 3.A.7.15.1 (Flp-1). As in March 2016, their precise functions appear to be unknown. A representative list of proteins belonging to the FFPP-Hol family can be found in the Transporter Classification Database.^[1]

See also

• Holin
• Lysin
• Transporter Classification Database

Further reading

• Reddy, BL; Saier, MH (2013). "Topological and phylogenetic analyses of bacterial holin families and superfamilies". Biochim. Biophys. Acta. 1828: 2654–71. doi:10.1016/j.bbamem.2013.07.004. PMC 3788059. PMID 23856191..
• Saier, MH; Reddy, BL (2015). "Holins in bacteria, eukaryotes, and archaea: multifunctional xenologues with potential biotechnological and biomedical applications". J. Bacteriol. 197: 7–17. doi:10.1128/JB.02046-14. PMC 4288690. PMID 25157079..
• Wang, IN; Smith, DL; Young, R (2000). "Holins: the protein clocks of bacteriophage infections". Annu. Rev. Microbiol. 54: 799–825. doi:10.1146/annurev.micro.54.1.799. PMID 11018145..
• Young, R; Bläsi, U (1995). "Holins: form and function in bacteriophage lysis". FEMS Microbiol. Rev. 17: 191–205. PMID 7669346..