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Mescaline-FLY
Pharmaceutical compound From Wikipedia, the free encyclopedia
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Mescaline-FLY, also known as flyscaline, M-FLY, or MeO-2C-2,6-IFLY, is a putatively non-hallucinogenic serotonin receptor modulator of the phenethylamine, scaline, and FLY families.[1][2][3][4] It is the FLY (benzodifuran) analogue of the psychedelic drug mescaline.[1][2][3][4]
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Pharmacology
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Mescaline-FLY shows affinity for the serotonin 5-HT2 receptors.[3] Its affinities (Ki) were 335 to 4,443 nM for the serotonin 5-HT2A receptor, 205 to 302 nM for the serotonin 5-HT2B receptor, and 61.5 to 654 nM for the serotonin 5-HT2C receptor.[3] The affinity of mescaline-FLY for the serotonin 5-HT2A receptor was only slightly higher than that of mescaline, whereas it showed several-fold higher affinity for the serotonin 5-HT2C receptor and about 2-fold higher affinity for the serotonin 5-HT2B receptor compared to mescaline.[3] In a subsequent study, at the serotonin 5-HT2A receptor, its affinity (K0.5) was 243 nM and its EC50 (Emax ) was 3,470 nM (57%), relative to respective values for mescaline of 801 nM and 2,700 nM (88%).[5] Hence, whereas mescaline is a full agonist of the serotonin 5-HT2A receptor, mescaline-FLY is a moderate-efficacy partial agonist of the receptor.[5]
The drug failed to substitute for LSD in rodent drug discrimination tests, producing a maximum substitution of 29% at a dose of 55.2 μmol/kg, whereas mescaline fully substituted for LSD with an ED50 of 33.5 μmol/kg.[3][4][6][7][8] The lack of substitution with mescaline-FLY is in notable contrast to findings with other FLY drugs, such as 2C-B-FLY, DOB-FLY, and Bromo-DragonFLY.[6][7][8][9] Mescaline-FLY is not known to have been tested in humans, and hence it is unknown whether it produces psychedelic effects in humans.[1] However, based on its lack of psychedelic-like effects in rodent drug discrimination tests, it may not be expected to be hallucinogenic in humans.[3][4]
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History
Mescaline-FLY was first described in the scientific literature by the lab of David E. Nichols and colleagues by 1995.[3][4]
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