Formaldehyde transketolase

In enzymology, a formaldehyde transketolase (EC 2.2.1.3) is an enzyme that catalyzes the chemical reaction

D-xylulose 5-phosphate + formaldehyde ${\displaystyle \rightleftharpoons }$ glyceraldehyde 3-phosphate + glycerone

formaldehyde transketolase
Identifiers
EC no.	2.2.1.3
CAS no.	76774-46-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are D-xylulose 5-phosphate and formaldehyde, whereas its two products are glyceraldehyde 3-phosphate and glycerone.

This enzyme belongs to the family of transferases, specifically those transferring aldehyde or ketonic groups (transaldolases and transketolases, respectively). The systematic name of this enzyme class is D-xylulose-5-phosphate:formaldehyde glycolaldehydetransferase. This enzyme is also called dihydroxyacetone synthase. This enzyme participates in methane metabolism. It employs one cofactor, thiamin diphosphate.