Formate—dihydrofolate ligase

In enzymology, a formate—dihydrofolate ligase (EC 6.3.4.17) is an enzyme that catalyzes the chemical reaction

ATP + formate + dihydrofolate ${\displaystyle \rightleftharpoons }$ ADP + phosphate + 10-formyldihydrofolate

Formate—dihydrofolate ligase
Identifiers
EC no.	6.3.4.17
CAS no.	123303-25-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The 3 substrates of this enzyme are ATP, formate, and dihydrofolate, whereas its 3 products are ADP, phosphate, and 10-formyldihydrofolate.

This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is formate:dihydrofolate ligase (ADP-forming).