Formate dehydrogenase (NADP+)

In enzymology, a formate dehydrogenase (NADP+) (EC 1.17.1.10) is an enzyme that catalyzes the chemical reaction

formate + NADP⁺ ${\displaystyle \rightleftharpoons }$ CO₂ + NADPH

formate dehydrogenase (NADP+)
Identifiers
EC no.	1.17.1.10
CAS no.	51377-43-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are formate and NADP⁺, whereas its two products are CO₂ and NADPH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is formate:NADP+ oxidoreductase. Other names in common use include NADP+-dependent formate dehydrogenase, and formate dehydrogenase (NADP+). This enzyme participates in methane metabolism. It has 3 cofactors: iron, Tungsten, and Selenium.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2GSD.