Formate dehydrogenase (cytochrome)

In enzymology, a formate dehydrogenase (cytochrome) (EC 1.2.2.1) is an enzyme that catalyzes the chemical reaction

formate + 2 ferricytochrome b₁ ${\displaystyle \rightleftharpoons }$ CO₂ + 2 ferrocytochrome b₁ + 2 H⁺

formate dehydrogenase (cytochrome)
Formate dehydrogenase-N hetero9mer, E.Coli
Identifiers
EC no.	1.2.2.1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are formate and ferricytochrome b1, whereas its 3 products are CO₂, ferrocytochrome b1, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with a cytochrome as acceptor. The systematic name of this enzyme class is formate:ferricytochrome-b1 oxidoreductase. Other names in common use include formate dehydrogenase, and formate:cytochrome b1 oxidoreductase. This enzyme participates in glyoxylate and dicarboxylate metabolism.