Fructose-2,6-bisphosphate 2-phosphatase

The enzyme fructose-2,6-bisphosphate 2-phosphatase ({EC 3.1.3.46) catalyzes the reaction

β-D-fructose 2,6-bisphosphate + H₂O ${\displaystyle \rightleftharpoons }$ D-fructose 6-phosphate + phosphate

fructose-2,6-bisphosphate 2-phosphatase
Identifiers
EC no.	3.1.3.46
CAS no.	81611-75-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name is β-D-fructose-2,6-bisphosphate 2-phosphohydrolase. Other names in common use include fructose-2,6-bisphosphatase, and D-fructose-2,6-bisphosphate 2-phosphohydrolase. This enzyme participates in fructose and mannose metabolism.

Structural studies

As of late 2007, 13 structures have been solved for this class of enzymes, with PDB accession codes 1BIF, 1C7Z, 1C80, 1C81, 1FBT, 1K6M, 1TIP, 2AXN, 2BIF, 2DWO, 2DWP, 2I1V, and 3BIF.