Galactosylceramidase

Galactosylceramidase (or galactocerebrosidase), EC 3.2.1.46, is an enzyme that removes galactose from ceramide derivatives (galactosylceramides) by catalysing the hydrolysis of galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride.^[1]

Galactosylceramidase
Identifiers
EC no.	3.2.1.46
CAS no.	9027-89-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

It is a lysosomal protein, encoded in humans by the GALC gene.^[1][2] Mutations in this gene have been associated with Krabbe disease, also known as galactosylceramide lipidosis.^[1]