GDP-4-dehydro-6-deoxy-D-mannose reductase

In enzymology, a GDP-4-dehydro-6-deoxy-D-mannose reductase (EC 1.1.1.281) is an enzyme that catalyzes the chemical reaction

GDP-6-deoxy-D-mannose + NAD(P)⁺ ${\displaystyle \rightleftharpoons }$ GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H⁺

GDP-4-dehydro-6-deoxy-D-mannose reductase
Identifiers
EC no.	1.1.1.281
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

The 3 substrates of this enzyme are GDP-6-deoxy-D-mannose, NAD⁺, and NADP⁺, whereas its 4 products are GDP-4-dehydro-6-deoxy-D-mannose, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is GDP-6-deoxy-D-mannose:NAD(P)⁺ 4-oxidoreductase (D-rhamnose-forming). Other names in common use include GDP-4-keto-6-deoxy-D-mannose reductase [ambiguous], GDP-6-deoxy-D-lyxo-4-hexulose reductase, and Rmd. This enzyme participates in fructose and mannose metabolism.