Galactose 1-dehydrogenase (NADP+)

In enzymology, a galactose 1-dehydrogenase (NADP⁺) (EC 1.1.1.120) is an enzyme that catalyzes the chemical reaction

D-galactose + NADP⁺ ${\displaystyle \rightleftharpoons }$ D-galactono-1,5-lactone + NADPH + H⁺

galactose 1-dehydrogenase (NADP+)
Identifiers
EC no.	1.1.1.120
CAS no.	37250-51-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are D-galactose and NADP⁺, whereas its 3 products are D-galactono-1,5-lactone, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is D-galactose:NADP⁺ 1-oxidoreductase. Other names in common use include D-galactose dehydrogenase (NADP⁺), and galactose 1-dehydrogenase (NADP⁺). This enzyme participates in galactose metabolism.