Galactosylceramide sulfotransferase

In enzymology, a galactosylceramide sulfotransferase (EC 2.8.2.11) is an enzyme that catalyzes the chemical reaction

3'-phosphoadenylyl sulfate + a galactosylceramide ${\displaystyle \rightleftharpoons }$ adenosine 3',5'-bisphosphate + a galactosylceramidesulfate

galactosylceramide sulfotransferase
Identifiers
EC no.	2.8.2.11
CAS no.	9081-06-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, its two substrates are 3'-phosphoadenylyl sulfate and galactosylceramide, and its two products are adenosine 3',5'-bisphosphate and galactosylceramidesulfate.

It belongs to the family of transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:galactosylceramide 3'-sulfotransferase. Other names in common use include GSase, 3'-phosphoadenosine-5'-phosphosulfate-cerebroside sulfotransferase, galactocerebroside sulfotransferase, galactolipid sulfotransferase, glycolipid sulfotransferase, and glycosphingolipid sulfotransferase. This enzyme participates in sphingolipid metabolism.