Gluconolactonase

The enzyme gluconolactonase (EC 3.1.1.17) catalyzes the reaction

D-glucono-1,5-lactone + H₂O ${\displaystyle \rightleftharpoons }$ D-gluconate

gluconolactonase
Gluconolactonase homodimer, Xanthomonas campestris
Identifiers
EC no.	3.1.1.17
CAS no.	9012-73-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name is D-glucono-1,5-lactone lactonohydrolase. Other names in common use include lactonase, aldonolactonase, glucono-δ-lactonase, and gulonolactonase. This enzyme participates in three metabolic pathways: pentose phosphate pathway, ascorbate and aldarate metabolism, and caprolactam degradation.