Glucose-6-phosphate 1-epimerase

In enzymology, a glucose-6-phosphate 1-epimerase (EC 5.1.3.15) is an enzyme that catalyzes the chemical reaction

alpha-D-glucose 6-phosphate ${\displaystyle \rightleftharpoons }$ beta-D-glucose 6-phosphate

glucose-6-phosphate 1-epimerase
Identifiers
EC no.	5.1.3.15
CAS no.	37259-65-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Hence, this enzyme has one substrate, alpha-D-glucose 6-phosphate, and one product, beta-D-glucose 6-phosphate.

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on carbohydrates and derivatives. The systematic name of this enzyme class is D-glucose-6-phosphate 1-epimerase. This enzyme participates in glycolysis / gluconeogenesis.

Structural studies

As of late 2013, 3 structures have been solved for this class of enzymes, with PDB accession codes 2CIQ, 2CIR, and 2CIS.