Glucose 1-dehydrogenase

For other uses, see Glucose 1-dehydrogenase (disambiguation).

In enzymology, a glucose 1-dehydrogenase (EC 1.1.1.47) is an enzyme that catalyzes the chemical reaction

beta-D-glucose + NAD(P)⁺ ${\displaystyle \rightleftharpoons }$ D-glucono-1,5-lactone + NAD(P)H + H⁺

glucose 1-dehydrogenase
Glucose dehydrogenase tetramer, Caenorhabditis Elegans
Identifiers
EC no.	1.1.1.47
CAS no.	9028-53-9
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The 3 substrates of this enzyme are beta-D-glucose, NAD⁺, and NADP⁺, whereas its 4 products are D-glucono-1,5-lactone, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is beta-D-glucose:NAD(P)⁺ 1-oxidoreductase. Another name in common use is D-glucose dehydrogenase (NAD(P)⁺).

Structural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1G6K, 1GCO, 1GEE, 1RWB, 1SPX, 2B5V, 2B5W, 2CD9, and 2CDA.