Glutamine—fructose-6-phosphate transaminase (isomerizing)

In enzymology, a glutamine-fructose-6-phosphate transaminase (isomerizing) (EC 2.6.1.16) is an enzyme that catalyzes the chemical reaction

L-glutamine + D-fructose 6-phosphate ${\displaystyle \rightleftharpoons }$ L-glutamate + D-glucosamine 6-phosphate

glutamine-fructose-6-phosphate transaminase (isomerizing)
Glutamine—fructose-6-phosphate transaminase 1, homodimer, Human
Identifiers
EC no.	2.6.1.16
CAS no.	9030-45-9
Alt. names	hexosephosphate aminotransferase glucosamine-6-phosphate isomerase (glutamine-forming) glutamine-fructose-6-phosphate transaminase (isomerizing) D-fructose-6-phosphate amidotransferase glucosaminephosphate isomerase glucosamine 6-phosphate synthase GlcN6P synthase
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are L-glutamine and D-fructose 6-phosphate, whereas its two products are L-glutamate and D-glucosamine 6-phosphate.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is L-glutamine:D-fructose-6-phosphate isomerase (deaminating). This enzyme participates in glutamate metabolism and aminosugars metabolism.

Structural studies

As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes 1JXA, 1MOQ, 1MOR, 1MOS, 1XFF, 1XFG, 2BPL, 2J6H, 2POC, 2PUT, 2PUV, and 2PUW.