Glutamine—phenylpyruvate transaminase

In enzymology, a glutamine-phenylpyruvate transaminase (EC 2.6.1.64) is an enzyme that catalyzes the chemical reaction

L-glutamine + phenylpyruvate ${\displaystyle \rightleftharpoons }$ 2-oxoglutaramate + L-phenylalanine

glutamine-phenylpyruvate transaminase
Identifiers
EC no.	2.6.1.64
CAS no.	68518-06-9
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are L-glutamine and phenylpyruvate, whereas its two products are 2-oxoglutaramate and L-phenylalanine.

This enzyme belongs to the family of transferases, to be specific, the transaminases, that transfer nitrogenous groups. The systematic name of this enzyme class is L-glutamine:phenylpyruvate aminotransferase. Other names in common use include glutamine transaminase K, and glutamine-phenylpyruvate aminotransferase. It employs one cofactor, pyridoxal phosphate.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1YIY and 1YIZ.