Glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating)

In enzymology, a glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) (EC 1.2.1.13) is an enzyme that catalyzes the chemical reaction

D-glyceraldehyde 3-phosphate + phosphate + NADP⁺ ${\displaystyle \rightleftharpoons }$ 3-phospho-D-glyceroyl phosphate + NADPH + H⁺

glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating)
Identifiers
EC no.	1.2.1.13
CAS no.	37250-87-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The 3 substrates of this enzyme are D-glyceraldehyde 3-phosphate, phosphate, and NADP⁺, whereas its 3 products are 3-phospho-D-glyceroyl phosphate, NADPH, and H⁺.

Function

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. This enzyme participates in the Calvin cycle which is an autotrophic carbon fixation pathway.

Nomenclature

The systematic name of this enzyme class is D-glyceraldehyde-3-phosphate:NADP+ oxidoreductase (phosphorylating). Other names in common use include:

• dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine dinucleotide phosphate) (phosphorylating)
• GAPDH
• glyceraldehyde phosphate dehydrogenase (nicotinamide adenine dinucleotide phosphate) (phosphorylating)
• glyceraldehyde-3-phosphate dehydrogenase (NADP) (phosphorylating)
• NADP-dependent glyceraldehyde phosphate dehydrogenase
• NADP-glyceraldehyde phosphate dehydrogenase
• NADP-glyceraldehyde-3-phosphate dehydrogenase
• NADP-triose phosphate dehydrogenase
• triosephosphate dehydrogenase (NADP)