Glycerol 2-dehydrogenase (NADP+)

In enzymology, a glycerol 2-dehydrogenase (NADP⁺) (EC 1.1.1.156) is an enzyme that catalyzes the chemical reaction

glycerol + NADP⁺ ${\displaystyle \rightleftharpoons }$ glycerone + NADPH + H⁺

glycerol 2-dehydrogenase (NADP+)
Identifiers
EC no.	1.1.1.156
CAS no.	39342-20-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are glycerol and NADP⁺, whereas its 3 products are glycerone, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is glycerol:NADP⁺ 2-oxidoreductase (glycerone-forming). Other names in common use include dihydroxyacetone reductase, dihydroxyacetone (reduced nicotinamide adenine dinucleotide, phosphate) reductase, dihydroxyacetone reductase (NADPH), DHA oxidoreductase, and glycerol 2-dehydrogenase (NADP⁺). This enzyme participates in glycerolipid metabolism.