Glycine/sarcosine/dimethylglycine N-methyltransferase

Glycine/sarcosine/dimethylglycine N-methyltransferase (EC 2.1.1.162, GSDMT, glycine sarcosine dimethylglycine N-methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:glycine(or sarcosine or N,N-dimethylglycine) N-methyltransferase (sarcosine(or N,N-dimethylglycine or betaine)-forming).^[1] This enzyme catalyses the following chemical reaction

3 S-adenosyl-L-methionine + glycine ${\displaystyle \rightleftharpoons }$ 3 S-adenosyl-L-homocysteine + betaine (overall reaction)

(1a) S-adenosyl-L-methionine + glycine ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + sarcosine

(1b) S-adenosyl-L-methionine + sarcosine ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + N,N-dimethylglycine

(1c) S-adenosyl-L-methionine + N,N-dimethylglycine ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + betaine

Glycine/sarcosine/dimethylglycine N-methyltransferase
Identifiers
EC no.	2.1.1.162
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

This enzyme from the halophilic methanoarchaeon Methanohalophilus portucalensis can methylate glycine and all of its intermediates to form the compatible solute trimethylglycine.