Glycoside hydrolase family 1

Glycoside hydrolase family 1 is a family of glycoside hydrolases. Glycoside hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.^[1][2][3] This classification is available on the CAZy web site,^[4][5] and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.^[6][7]

Glycosyl hydrolase family 1
Identifiers
Symbol	Glyco_hydro_1
Pfam	PF00232
Pfam clan	CL0058
InterPro	IPR001360
PROSITE	PDOC00495
SCOP2	1cbg / SCOPe / SUPFAM
OPM superfamily	117
OPM protein	3gnr
Membranome	522
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Glycoside hydrolase family 1 CAZY GH_1 comprises enzymes with a number of known activities; beta-glucosidase (EC 3.2.1.21); beta-galactosidase (EC 3.2.1.23); 6-phospho-beta-galactosidase (EC 3.2.1.85); 6-phospho-beta-glucosidase (EC 3.2.1.86); lactase-phlorizin hydrolase (EC 3.2.1.62), lactase (EC 3.2.1.108); beta-mannosidase (EC 3.2.1.25); myrosinase (EC 3.2.1.147).

Subfamilies

• 6-phospho-beta-galactosidase InterPro: IPR005928

Human proteins containing this domain

GBA3; KL; KLB; LCT; LCTL;

External links

• GH1 in CAZypedia