2-hydroxyisoflavanone dehydratase

The enzyme 2-hydroxyisoflavanone dehydratase (EC 4.2.1.105) catalyzes the chemical reaction

2,7,4′-trihydroxyisoflavanone ${\displaystyle \rightleftharpoons }$ daidzein + H₂O

2-hydroxyisoflavanone dehydratase
Identifiers
EC no.	4.2.1.105
CAS no.	56022-25-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 2,7,4′-trihydroxyisoflavanone hydro-lyase (daidzein-forming). This enzyme is also called 2,7,4′-trihydroxyisoflavanone hydro-lyase. This enzyme participates in isoflavonoid biosynthesis.

The variant GmHID1 from Glycine max converts 2-hydroxyisoflavone to isoflavones, mostly daidzein and genistein.^[1]