Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase

The enzyme guanosine-3′,5′-bis(diphosphate) 3′-diphosphatase (EC 3.1.7.2)^[1][2] catalyzes the reaction.

guanosine 3′,5′-bis(diphosphate) + H₂O ${\displaystyle \rightleftharpoons }$ GDP + diphosphate

guanosine-3′,5′-bis(diphosphate) 3′-diphosphatase
Identifiers
EC no.	3.1.7.2
CAS no.	70457-12-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

This enzyme belongs to the family of hydrolases, specifically of those acting on diphosphoric monoester bonds. The systematic name is guanosine-3′,5′-bis(diphosphate) 3′-diphosphohydrolase. Other names in common use include guanosine-3′,5′-bis(diphosphate) 3′-pyrophosphatase, PpGpp-3'-pyrophosphohydrolase, and PpGpp phosphohydrolase. This enzyme participates in purine metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1VJ7.