Helicase–primase complex

A helicase–primase complex (also helicase-primase, Hel/Prim, H-P or H/P) is a complex of enzymes including DNA helicase and DNA primase. A helicase-primase associated factor protein may also be present.^[1]

The complex is used by herpesviruses, in which it is responsible for lytic DNA virus replication.^[2][3][4] In many dsDNA viruses, primase and helicase are fused into a single polypeptide chain, so that the primase and helicase domains correspond to the N-terminal and C-terminal parts of the protein, respectively.^[5] A helicase-primase inhibitor (HPI) is a drug that blocks this action through acting as an enzyme inhibitor.

List of H-P by virus name

• EBV: helicase:BBLF4 primase: BSLF1 accessory protein:BBLF2/3^[2]

List of H-P inhibitors

• Amenamevir (ASP2151)^[6]
• Pritelivir (BAY 57–1293, AIC316)
• BILS 22 BS^[6]
• T157602^[6]