Hepatitis B virus PRE 1151–1410

Hepatitis B virus PRE 1151–1410 (HBV post-transcriptional regulatory element, nucleotides 1151–1410) is a part of 500 base pair long HBV PRE, that has been proposed to be the hepatitis B virus (HBV) RNA export element.^[1][2][3] However, the function is controversial and new regulatory elements have been predicted within PRE.^[4] PRE 1151–1410 enhances nuclear export of intronless transcripts and represses the splicing mechanism to a comparable degree to that of the full-length PRE. Hence it was proposed to be the core HBV PRE element.^[4] PRE1151–1410 contains 3 known regulatory elements: PRE SL-alpha (nucleotides 1292–1321),^[5] human La protein binding site (nucleotide 1275–1291),^[6] SRE-1 (nucleotides 1252–1348).^[7]

Hepatitis B virus PRE 1151–1410
Predicted secondary structure and sequence conservation of Hepatitis B virus PRE 1151–1410
Identifiers
Rfam	RF02816
Other data
Domain(s)	Viruses
GO	GO:0051168 ,GO:0043484
SO	SO:0005836
PDB structures	PDBe

See also

• HBV PRE SL alpha
• HBV PRE SL beta
• HBV RNA encapsidation signal epsilon