Histidine—tRNA ligase

In enzymology, a histidine-tRNA ligase (EC 6.1.1.21) is an enzyme that catalyzes the chemical reaction

ATP + L-histidine + tRNAHis ${\displaystyle \rightleftharpoons }$ AMP + diphosphate + L-histidyl-tRNAHis

histidine-tRNA ligase
Identifiers
EC no.	6.1.1.21
CAS no.	9068-78-4
Alt. names	histidyl tRNA synthetase, Jo-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The 3 substrates of this enzyme are ATP, L-histidine, and tRNA(His), whereas its 3 products are AMP, diphosphate, and L-histidyl-tRNA(His).

This enzyme participates in histidine metabolism and aminoacyl-trna biosynthesis.

Nomenclature

Histidine—tRNA ligase belongs to the family of ligase enzymes, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-histidine:tRNAHis ligase (AMP-forming). Other names in common use include histidyl-tRNA synthetase, histidyl-transfer ribonucleate synthetase, and histidine translase.

See also

• Anti-Jo1