Holo-ACP synthase

In enzymology, a holo-ACP synthase (EC 2.7.7.61) is an enzyme that catalyzes the chemical reaction

2'-(5"-triphosphoribosyl)-3'-dephospho-CoA + apo-citrate lyase ${\displaystyle \rightleftharpoons }$ holo-citrate lyase + diphosphate

holo-citrate lyase synthase
Identifiers
EC no.	2.7.7.61
CAS no.	312492-44-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are 2'-(5"-triphosphoribosyl)-3'-dephospho-CoA and apo-citrate lyase, whereas its two products are holo-citrate lyase and diphosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is 2'-(5"-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase adenylyltransferase. Other names in common use include 2'-(5"-phosphoribosyl)-3'-dephospho-CoA transferase, 2'-(5"-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase, and CitX. This enzyme participates in two-component system - general.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2BDD.