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Human herpesvirus 6A
Species of virus From Wikipedia, the free encyclopedia
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Human herpesvirus 6A (HHV-6A) is a species of virus in the genus Roseolovirus, subfamily Betaherpesvirinae, family Herpesviridae, and order Herpesvirales.[1][2]
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HHV-6A and infertility
- A 2016 study showed that 43% of women with unexplained infertility tested positive for HHV-6A while 0% of women in the fertile control group tested positive. HHV-6A was found present in endrometrial epithelial cells from women with unexplained infertility. [3]
- A 2018 study reports the prevalence of HHV-6A in endometrial biopsies among women experiencing recurrent implantation failure after IVF/ET compared to control groups.[4]
- A 2019 study confirmed the presence of HHV-6A infection in 40% of idiopathic infertile women. Identifying the effect of HHV-6A infection on endometrial immune status opens up a new perspectives on fertility care. It's possible to choose antiviral therapies and non-hormonal approaches for women with unexplained infertility characterized by HHV-6A to increase their pregnancy rate.[5]
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Taxonomy
In 1992 the two variants were recognised within Human herpesvirus 6 on the basis of differing restriction endonuclease cleavages, monoclonal antibody reactions,[6] and growth patterns.[7] In 2012 these two variants were officially recognised as distinct species by the International Committee on Taxonomy of Viruses.[8] Despite now being recognised as paraphyletic, the name Human herpesvirus 6 still sees usage in clinical contexts.
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Pathology
Human herpesvirus 6A affects humans and includes several adult-derived strains. Its disease spectrum is not well defined, although it is thought by some to be more neurovirulent than Human herpesvirus 6B.[9][10]
References
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