Hydroxyglutamate decarboxylase

The enzyme hydroxyglutamate decarboxylase (EC 4.1.1.16) catalyzes the chemical reaction

3-hydroxy-L-glutamate ${\displaystyle \rightleftharpoons }$ 4-amino-3-hydroxybutanoate + CO₂

hydroxyglutamate decarboxylase
Identifiers
EC no.	4.1.1.16
CAS no.	9024-59-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Hence, this enzyme has one substrate, 3-hydroxy-L-glutamate, and two products, 4-amino-3-hydroxybutanoate and CO₂.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 3-hydroxy-L-glutamate 1-carboxy-lyase (4-amino-3-hydroxybutanoate-forming). This enzyme is also called 3-hydroxy-L-glutamate 1-carboxy-lyase. It employs one cofactor, pyridoxal phosphate.