Hydroxymethylglutaryl-CoA hydrolase

The enzyme hydroxymethylglutaryl-CoA hydrolase (EC 3.1.2.5) catalyzes the reaction

S-(2-hydroxyacyl)glutathione + H₂O = glutathione + a 2-hydroxy carboxylate

hydroxymethylglutaryl-CoA hydrolase
Identifiers
EC no.	3.1.2.5
CAS no.	9025-89-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name is S-(2-hydroxyacyl)glutathione hydrolase. Other names in common use include β-hydroxy-beta-methylglutaryl coenzyme A hydrolase, β-hydroxy-β-methylglutaryl coenzyme A deacylase, hydroxymethylglutaryl coenzyme A hydrolase, hydroxymethylglutaryl coenzyme A deacylase, and 3-hydroxy-3-methylglutaryl-CoA hydrolase.