IRF2

Interferon regulatory factor 2 is a protein that in humans is encoded by the IRF2 gene.^[5]

IRF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1IRF, 1IRG, 2IRF
Identifiers
Aliases	IRF2, IRF-2, interferon regulatory factor 2
External IDs	OMIM: 147576; MGI: 96591; HomoloGene: 1659; GeneCards: IRF2; OMA:IRF2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q35.1 Start 184,385,702 bp[1] End 184,474,558 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 B1.1 Start 47,192,767 bp[2] End 47,300,493 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte blood Achilles tendon granulocyte olfactory zone of nasal mucosa appendix spleen lymph node rectum right adrenal cortex Top expressed in granulocyte blood left colon spleen left lobe of liver mesenteric lymph nodes muscle of thigh thymus duodenum tail of embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus focal adhesion nucleoplasm cytosol Biological process interferon-gamma-mediated signaling pathway cell population proliferation blood coagulation regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II type I interferon signaling pathway transcription, DNA-templated positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II immune system process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3660 16363 Ensembl ENSG00000168310 ENSMUSG00000031627 UniProt P14316 P23906 RefSeq (mRNA) NM_002199 NM_008391 RefSeq (protein) NP_002190 NP_032417 Location (UCSC) Chr 4: 184.39 – 184.47 Mb Chr 8: 47.19 – 47.3 Mb PubMed search [3] [4]
Wikidata
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Function

IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4.^[6]

See also

• IRF1
• Interferon regulatory factors

Interactions

IRF2 has been shown to interact with BRD7,^[7] EP300^[8] and PCAF.^[8][9]