Indolepyruvate C-methyltransferase

In enzymology, an indolepyruvate C-methyltransferase (EC 2.1.1.47) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + (indol-3-yl)pyruvate ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + (3S)-3-(indol-3-yl)-3-oxobutanoate

indolepyruvate C-methyltransferase
Identifiers
EC no.	2.1.1.47
CAS no.	54576-88-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are S-adenosyl methionine and (indol-3-yl)pyruvate, whereas its two products are S-adenosylhomocysteine and (3S)-3-(indol-3-yl)-3-oxobutanoate.

Nomenclature

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine: (indol-3-yl)pyruvate C-methyltransferase. Other names in common use include indolepyruvate methyltransferase, indolepyruvate 3-methyltransferase, indolepyruvic acid methyltransferase, and S-adenosyl-L-methionine:indolepyruvate C-methyltransferase. This enzyme participates in tryptophan metabolism.