Inosinate nucleosidase

In enzymology, an inosinate nucleosidase (EC 3.2.2.12) is an enzyme that catalyzes the chemical reaction

5'-inosinate + H₂O ${\displaystyle \rightleftharpoons }$ D-ribose 5-phosphate + hypoxanthine

inosinate nucleosidase
Identifiers
EC no.	3.2.2.12
CAS no.	37288-61-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are 5'-inosinate and H₂O, whereas its two products are D-ribose 5-phosphate and hypoxanthine.

This enzyme belongs to the family of hydrolases, specifically those glycosylases that hydrolyse N-glycosyl compounds. The systematic name of this enzyme class is 5'-inosinate phosphoribohydrolase. This enzyme participates in purine metabolism.